IN VITRO ANTIBACTERIAL ACTIVITY OF Schizophyllum commune FR. EXTRACTS
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Abstract
The purpose of this study was to study in vitro antibacterial activity
of Schizophyllum commune extracts. The antibacterial substances were
extracted from Schizophyllum commune by using 4 solvents including Hexane, Dichloromethane, Ethyl acetate, and Methanol. The extracts were determined an antibacterial activity against 6 pathogenic bacteria (Bacillus subtilis TISTR 008, Escherichia coli TISTR 780, Staphylococcus aureus TISTR. 1466, Staphylococcus epidermidis TISTR 518, Pseudomonas aeruginosa TISTR 1383, Klebsiella pneumoniae subsp. pneumoniae TISTR 1383). The results presented that the Minimum Inhibitory Concentration (MIC) was between 0.15-2.5 milligrams per milliliter. It was found that the extracts from Schizophyllum commune extracted with Ethyl acetate had the lowest MIC values against Staphylococcus aureus TISTR 1466 of 0.15 milligrams per milliliter, followed by the extract from Schizophyllum commune extracted using Hexane had a MIC value of 0.62 milligrams per milliliter. The results showed that only the extract from Schizophyllum commune extracted with Ethyl acetate showed the Minimum Bactericidal Concentration (MBC) against Staphylococcus aureus TISTR 1466 of 1.25 milligrams per milliliter. This study is the first report of the antibacterial activity against Staphylococcus aureus from the Schizophyllum commune extract which is beneficial to pharmaceutical development.
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References
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