ETHOSOMES PREPARATION OF HOM THONG BANANA PEEL EXTRACT FOR DEVELOPMENT OF COSMETICS

Abstract

The purpose of this research was to analyze the total phenolic, flavonoid contents and antioxidant activity of Hom Thong and Kluay Khai banana peel extracts and encapsulated with ethosomes particles for application in cosmeceuticals. Hom Thong and Kluai Khai peel banana extracts were extracted by soxhlet extraction using 70% ethanol that showed a decrease in total phenolic flavonoid contents and antioxidant activity according to unripe, semi-ripe and ripe stages. Unripe Hom Thong banana peel extract contained the highest amount of total phenolic content (243.00±0.39 mg GA/g), flavonoids (920.30±0.00 mg QE/100g), and antioxidant activity (308.82±2.05 mg TE/g) followed by unripe Kluai Khai banana peel extract (58.60±9.07 mg GA/g, 545.31±0.00 mg QE/100g, 25.98±1.02 mg TE/g). Ripe Kluai Khai banana peel extract exhibited the least amount of phenolic and flavonoids contents. The Hom Thong unripe banana peel extract (0.25% w/w) was prepared ethosomes using a high speed mixer homogenizer. The particle size of ethosomes (Z-Average) was 179.4±3.60 nm on the surface charge (Zeta-potential) -43.5±0.72 mV with a polydispersity index (PDI) 0.256±0.02. The entrapment efficiency of ethosomes loading Hom Thong unripe banana peel extract was 68.70±0.95.