OCCUPATIONAL EXPOSURE OF TRICHLOROETHYLENE: TOXICITY, CURRENT STANDARDS AND SUGGESTED NEW BIOMARKERS FOR KIDNEY CANCER

Authors

  • Worrawit Nakpan Sukhothai Thammathirat Open University

Keywords:

Trichloroethylene, Chemical exposure, Carcinogen, Occupational health, Workplace

Abstract

Trichloroethylene (TCE) is a well-known volatile organic compound. The chemical is widely used as a solvent for degreasing metal or electronic parts in industries. For years, the potential health risk associated with occupational exposure to TCE has been constantly studied. It has been known that the primary routes of TCE exposure are chemical inhalation and dermal absorption. The health effects are related to the period of exposure and the concentration. Short-term exposure to TCE may affect the nervous system, liver, kidneys and immune system, while long-term exposure has been linked to carcinogenic tumors in several target organs such as liver and kidneys. For the occupational exposure standpoint, the regulations and recommendations generated by U.S. federal government agencies were explained in this article. The mechanisms of action when TCE was absorbed into the body were also elaborated in detail. It was found that TCE can be metabolized into two different pathways: oxidation and conjugation. Each pathway has different target organs. For example, the oxidative pathway can mainly affect the liver, whereas the glutathione (GSH) conjugation goes to kidneys. For both acute and chronic effects, dose-response relationships were identified in this article. Thus, the objective of this article is to update the current situation and to review the toxicity of TCE with epidemiology data, especially kidney-related cancer, for better understanding.

References

ACGIH. (2019). 2019 TLVs and BEIs: Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agent and Biological Exposure Indices. Cincinnati, Ohio, USA: American Conference of Governmental Industrial Hygienists.

Al-Griw, M. A., Al-Azreg, S. A., Bennour, E. M., El-Mahgiubi, S. A. M., Al-Attar, A. R., Salama, N. M., & Elnfati, A. S. (2015). Fertility and reproductive outcome in mice following Trichloroethane (TCE) exposure. American Journal of Life Science Researches, 3(4), 293–303.

Bakke, B., Stewart, P. A., & Waters, M. A. (2007). Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. Journal of Occupational and Environmental Hygiene, 4(5), 375–390.

Brauch, H., Weirich, G., Hornauer, M. A., Störkel, S., Wöhl, T., & Brüning, T. (1999). Trichloroethylene Exposure and Specific Somatic Mutations in Patients With Renal Cell Carcinoma. Journal of the National Cancer Institute, 91(10), 854–868.

Brüning, T., & Bolt, H. M. (2000). Renal Toxicity and Carcinogenicity of Trichloroethylene: Key Results, Mechanisms, and Controversies. Critical Reviews in Toxicology, 30(3), 253–285.

Chittasobhaktra, T., Wannanukul, W., Wattanakrai, P., Pramoolsinsap, C., Sohonslitdsuk, A., & Nitiyanant, P. (1997). Fever, skin rash, jaundice and lymphadenopathy after trichloroethylene exposure: a case report. Journal of the Medical Association of Thailand= Chotmaihet Thangphaet, 80, S144-8.

Chiu, W. A., Jinot, J., Scott, C. S., Makris, S. L., Cooper, G. S., Dzubow, R. C., … Caldwell, J. C. (2012). Human Health Effects of Trichloroethylene: Key Findings and Scientific Issues. Environmental Health Perspectives, 121(3), 303–311.

Cummings, B. S., Parker, J. C., & Lash, L. H. (2000). Role of cytochrome P450 and glutathione S-transferase

α in the metabolism and cytotoxicity of trichloroethylene in rat kidney. Biochemical Pharmacology, 59(5), 531–543.

Desimone, M. C., Rathmell, W. K., & Threadgill, D. W. (2013). Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. Journal of the National Cancer Institute, 105(18), 1355–1364.

Dodge, D. G., & Goodman, J. E. (2015). Trichloroethylene. In R.D. Harbison, M.M. Bourgeois and G.T. Johnson (Eds.), Hamilton & Hardy’s Industrial Toxicology (pp. 733–740). Hoboken, New Jersey, USA: John Wiley & Sons, Inc.

Fan, X., Wang, G., English, R. D., & Firoze Khan, M. (2014). Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice. Toxicology Mechanisms and Methods, 24(1), 21–30.

Forkert, P. G., Sylvestre, P. L., & Poland, J. S. (1985). Lung injury induced by trichloroethylene. Toxicology, 35(2), 143–160.

Gilbert, K. M., Blossom, S. J., Erickson, S. W., Broadfoot, B., West, K., Bai, S., … Cooney, C. A. (2016). Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells. Toxicology Letters, 260, 1–7.

Green, T. (2004). Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene. Occupational and Environmental Medicine, 61(4), 312–317.

Hansen, J., Sallmén, M., Seldén, A. I., Anttila, A., Pukkala, E., Andersson, K., … McLaughlin, J. K. (2013). Risk of cancer among workers exposed to trichloroethylene: analysis of three Nordic cohort studies. Journal of the National Cancer Institute, 105(12), 869–877.

Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., … Linehan, W. M. (1994). Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proceedings of the National Academy of Sciences, 91(21), 9700–9704.

Hudson, N., & Dotson, G. S. (2017). NIOSH skin notation (SK) profiles: trichloroethylene (TCE)[CAS No. 79-01-6]. Retrieved August 20, 2019, from https://www.cdc.gov/niosh/docs/2017-192/2017-192.pdf

Humans, I. W. G. on the E. of C. R. to. (2014). Trichloroethylene, Tetrachloroethylene, and Some Other Chlorinated Agents. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 106, 1.

Johnson, P. D., Goldberg, S. J., Mays, M. Z., & Dawson, B. V. (2003). Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat. Environmental Health Perspectives, 111(3), 289–292.

Kim, I., Ha, J., Lee, J.-H., Yoo, K.-M., & Rho, J. (2014). The Relationship between the Occupational Exposure of Trichloroethylene and Kidney Cancer. Annals of Occupational and Environmental Medicine, 26(1), 12.

Kim, S., Kim, D., Pollack, G. M., Collins, L. B., & Rusyn, I. (2009). Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology and Applied Pharmacology, 238(1), 90–99.

Kishi, R., Harabuchi, I., Ikeda, T., Katakura, Y., & Miyake, H. (1993). Acute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans. Occupational and Environmental Medicine, 50(5), 470–480.

Lash, L. H., Chiu, W. A., Guyton, K. Z., & Rusyn, I. (2014). Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity. Mutation Research. Reviews in Mutation Research, 762, 22–36.

Lash, L. H., Putt, D. A., & Parker, J. C. (2006). Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine. Journal of Toxicology and Environmental Health. Part A, 69(13), 1285–1309.

Loch-Caruso, R., Hassan, I., Harris, S. M., Kumar, A., Bjork, F., & Lash, L. H. (2019). Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats. Reproductive Toxicology, 83, 38–45.

Moore, L. E., Boffetta, P., Karami, S., Brennan, P., Stewart, P. S., Hung, R., … Rothman, N. (2010). Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Research, 70(16), 6527–6536.

Moore, L. E., Nickerson, M. L., Brennan, P., Toro, J. R., Jaeger, E., Rinsky, J., … Rothman, N. (2011). Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors. PLoS Genetics, 7(10), e1002312.

NIOSH. (2018). Trichloroethylene. In NIOSH pocket guide to chemical hazards. Cincinnati, Ohio: US Department of Health and Human Services. Center of Disease Control and Prevention, National Institute for Occupational Safety and Health.

Niu, X., Zhang, T., Liao, L., Zhou, L., Lindner, D. J., Zhou, M., … Yang, H. (2011). The von Hippel–Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene, 31(6), 776–786.

NTP. (2016). Trichloroethylene. Retrieved August 20, 2019, from https://ntp.niehs.nih.gov/pubhealth/roc/index-1.html.

OSHA. (2004). Trichloroethylene. Retrieved March 30, 2016, form https://www.osha.gov/dts/chemicalsampling/

data/CH_273000.html.

Sangchom, S. (2009). Health effects of occupational exposure to Trichloroethylene in Thailand. Weekly Epidemiological Surveillance Report, 40(7), 273–277.

Singthong, S., Pakkong, P., Choosang, K., & Wongsanit, S. (2015). Occupational health risks among trichloroethylene-exposed workers in a clock manufacturing factory. Global Journal of Health Science, 7(1), 161–172.

Todd, G. D., Ruiz, P., Mumtaz, M., Wohlers, D., Klotzbach, J. M., Diamond, G. L., … Citra, M. J. (2019). Toxicological profile for trichloroethylene (TCE). Retrieved August 20, 2019, from https://www.atsdr.cdc.gov/ToxProfiles/tp19.pdf

USEPA. (2011). IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft). Retrieved August 20, 2019, from https://doi.org/https://www.epa.gov/iris/toxreviews/0070tr.pdf

Vermeulen, R., Zhang, L., Spierenburg, A., Tang, X., Bonventre, J. V, Reiss, B., … Lan, Q. (2012). Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis, 33(8), 1538–1541.

Vlaanderen, J., Straif, K., Pukkala, E., Kauppinen, T., Kyyrönen, P., Martinsen, J. I., … Weiderpass, E. (2013). Occupational exposure to trichloroethylene and perchloroethylene and the risk of lymphoma, liver, and kidney cancer in four Nordic countries. Occupational and Environmental Medicine, 70(6), 393–401.

Yoo, H. S., Bradford, B. U., Kosyk, O., Uehara, T., Shymonyak, S., Collins, L. B., … Rusyn, I. (2015). Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. Journal of Toxicology and Environmental Health. Part A, 78(1), 32–49.

Zamanian, Z., Yousefinejad, S., Khoshnoud, M. J., Golbabaie, F., Zare, M. R., Modaresi, A., … Rahmani, A. (2019). Toxicological Effects of Inhalation Exposure to Trichloroethylene on Serum Immunoglobulin and Electrolyte Levels in Rats. Health Scope, 8(3). 1-7.

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Published

2019-12-19

How to Cite

Nakpan, W. (2019). OCCUPATIONAL EXPOSURE OF TRICHLOROETHYLENE: TOXICITY, CURRENT STANDARDS AND SUGGESTED NEW BIOMARKERS FOR KIDNEY CANCER. PSRU Journal of Science and Technology, 5(1), 1–12. Retrieved from https://ph01.tci-thaijo.org/index.php/Scipsru/article/view/214092

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Review Articles