Development of effervescent tablets formulation yathat-opchoei extract ความคงตัวของผลิตภัณฑ์เม็ดฟู่ละลายน้ำของยาธาตุอบเชย

Abstract

Purposes : The aims of this study were investigated to develop an effervescent tablet formulation from Thunbergia yathat-opchoei extract to has the best stability

Study Design: Quasi-experimental study.

Materials and Methods: The effervescent tablet composed of citric acid, tartaric acid, sodium bicarbonate, sweetener, anti adheren, lubricant, and flavor. It was prepared by wet granulation method using water, and compressed with a single punch tableting machine. Amount of Rang Chuet extraction required for one tablet. The appropriate formulation was selected by its taste and compactability. Obtaining effervescent tablets were then evaluated in terms of weigh variation, hardness, disintegration time tested at 0, 15, 30, 60, 90 and 120 days.

Main findings : The effervescent tablet indicated that 5 %w/w of Rang Chuet extract was required for one tablet. The most satisfactory effervescent tablet formulation in terms of taste and physical property consisted of citric acid 25%w/w, Sodium bicarbonate 34 %w/w, Tapioca flour 30%w/w, PVP–K90 3%w/w, Magnesium stearate  2 %w/w, aerosil®  1%w/w. It had hardness of 5.276, 5.222, 5.212, 5.190, 5.178 and 4.984 kp, disintegration time at 5.14, 5.19, 4.95, 4.90, 4.72 and 4.52  minutes. The weight variation of 0.420, 0.419, 0.419, 0.417, 0.416 and 0.415 g. According to the Notification of Ministry of Public Health and World Health Organization, the heavy metals and microbial contamination values in traditional drugs from this work were acceptable. The further study should develop the manufacturing process for industrial scale production.