Antibacterial activity of Rosa damascena Extract against Acne- Inducing Bacteria (Cutibacterium acnes)
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Abstract
This study aimed to evaluate the antibacterial activity of crude ethanolic extract from Rosa damascena petals against Cutibacterium acnes, an anaerobic bacterium that plays a significant role in the pathogenesis of inflammatory acne, a common dermatological condition in the general population. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using the broth macro-dilution method at concentrations of 200, 100, 50, 25, 12.5, 6.25, 3.125, and 1.5625 mg/mL. The crude extract was obtained using 95% ethanol, yielding 6.41% (w/w) of the dried petal weight.
The results revealed that the extract exhibited both inhibitory and bactericidal effects against C. acnes with MIC and MBC values of 6.25 mg/mL. In comparison, tetracycline a commonly used antibiotic in acne treatment demonstrated significantly lower MIC and MBC values of 0.9375 µg/mL, indicating superior antibacterial efficacy. However, prolonged use of antibiotics may contribute to the emergence of resistant bacterial strains.
Therefore, R. damascena extract presents a promising natural alternative for the development of anti-acne skincare products or therapeutic agents. Utilizing plant-derived antimicrobials may help reduce dependency on antibiotics and mitigate the risk of antibiotic resistance, offering long-term benefits to public health.
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ความคิดเห็นและข้อเสนอแนะใดๆ ที่นำเสนอในบทความเป็นของผู้เขียนแต่เพียงผู้เดียว โดยบรรณาธิการ กองบรรณาธิการ และคณะกรรมการวารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยปทุมธานี ไม่ได้มีส่วนเกี่ยวข้องแต่อย่างใด มหาวิทยาลัย บรรณาธิการ และกองบรรณาธิการจะไม่รับผิดชอบต่อข้อผิดพลาดหรือผลที่เกิดจากการใช้ข้อมูลที่ปรากฏในวารสารฉบับนี้
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