Anti Cutibacterium acnes properties from Cannabis sativa

Jeerapar Noiseeluang

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Jeerapar Noiseeluang Faculty of allied health sciences, Pathumthani University

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Keyword Cannabis, Acne vulgaris, Phytochemical, Anti-bacteria, dermatology

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The antimicrobial potential of various cannabis compounds against Cutibacterium acnes
(C. acnes) remains a subject of significant interest in dermatological research. This review aims to elucidate the mechanisms underlying the antibacterial activity of major cannabis compounds, including cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinodiol (CBND), tetrahydrocannabinolic acid (THCA), Δ9-trans-tetrahydrocannabinol (Δ9-THC), Δ8-trans-tetrahydrocannabinol (Δ8-THC), cannabigerol (CBG), and cannabigerolic acid (CBGA). Many cannabis compounds showed antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), methicillin-resistant S. aureus (MRSA), and C. acnes, by acting as detergents and permeabilizing bacterial cell membranes by disrupting bacterial biofilms and membrane integrity. Some compounds, such as THCA, the precursor to THC, and THC derivatives, have shown inhibitory effects against staphylococci and streptococci bacteria, but their specific impact on C. acnes requires further investigation. In conclusion, while several cannabis compounds show promising antibacterial activity against various pathogens, including C. acnes, further research

is warranted to elucidate their precise mechanisms of action and therapeutic potential in dermatological applications. These findings underscore the importance of investigating cannabis-derived compounds as potential agents for combating bacterial infections, including those affecting the skin. These findings underscore the importance of investigating cannabis-derived compounds as potential agents for combating bacterial infections, including those affecting the skin.

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Anti Cutibacterium acnes properties from Cannabis sativa

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