Antioxidant and a-Glucosidase Inhibitory Activities of Young Jackfruit (Artocarpus heterophyllus) Extract

Abstract

In this research, hexane, dichloromethane and methanol crude extracts of young jackfruit (Artocarpus heterophyllus) were first evaluated for antioxidant activities, total phenolic contents and a-glucosidase inhibitory activity. Investigation of antioxidant activities included 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability, total phenolic contents using the Folin-Ciocalteau method. The methanol extract showed the highest DPPH radical scavenging (IC₅₀ 0.60 ± 0.18 mg/mL) and total phenolic contents (144.76 ± 2.30 mg gallic acid equivalent/g extract). In addition, the methanol extract revealed highest a-glucosidase inhibitory activity against rat intestinal sucrase with an IC₅₀ value of 25.32 ± 8.36 mg/mL while the dichloromethane extract demonstrated inhibitory effect against yeast a-glucosidase with an IC₅₀ value of 57.44 ± 10.36 mg/mL. These results suggest that the young jackfruit has a potential to be used for diabetes therapy.