Chemical Constituents from Clausena harmandiana Leaves

Abstract

Phytochemical investigation of Clausena harmandiana leaves led to the isolation and identification of six known compounds; methyl carbazole-3-carboxylate (1), clausemine D (2), clausine F (3), heptaphylline (4), p-anethole (5) and p-methoxybenzoic acid (6). All structures were characterized by mainly ¹H NMR spectral data as well as comparison with the reported known compounds. Crude extract and carbazole alkaloids 1-4 were also evaluated for antibacterial, antioxidant, α-glucosidase inhibitory and acetylcholinesterase inhibitory activities.