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The study of research was to develop the computer-assisted instruction by using the theory of Self-Directed Learning (SDL): Subject presentation program on using Microsoft PowerPoint program; compare pre-school and post-study of the Self-Directed Learning (SDL) for the students, and verify about the student’s learning satisfaction with CAI based on Self-Directed Learning (SDL). Also, the population and the sampling were 30 students who studied at Grade 12 Section 3, Kuraburi Chaipattana Pittayakom School, Kuraburi District, Phang Nga Province. The research instruments concluded with the computer-assisted instructions combined with 1) Self-Directed Learning test (SDL test), 2) quality assessment test, 3) the measuring academic achievements are the pre-test and post-test for the students, and 4) student satisfaction assessment. This research statistic used mean, standard deviation (SD), and t-test. The results found that the experts commented that content quality was excellent; 1) three units of the computer-assisted instruction and developed Self-Directed Learning (SDL) techniques. The mean and the standard deviation (SD) were 4.20 and .48. The lesson design aspect was excellent, with a mean and a standard deviation (SD) of 4.10 and .50; 2) the result of evaluating the effectiveness using the E1/E2 criterion was 82.04/83.98, which was higher than the 80/80 threshold; 3) the score of post-test was higher than the pre-test score significantly at .05; and 4) the lesson satisfaction of students found that it was at a very high level, the average is an equal with a mean and a standard deviation (SD) of 4.20 and .48.
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