Synthesis of Hydroxyxanthones and Evaluations for their Acetylcholinesterase Inhibitory and Neurotoxicity Activities

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Published: Mar 30, 2014
Keywords:
Hydroxythioxanthone Alzheimer’s disease Anti-acetylcholinesterase Neurotoxicity

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Thongchai Khammee
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110 Thailand
Anan Athipornchai
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240 Thailand
Wanchalerm Upamaia
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110 Thailand
Yamaratee Jaisin
Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok, 10110 Thailand
Sunit Suksamrarn
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110 Thailand

Abstract

A series of hydroxyxanthones has been synthesized and screened for their anti-AChE activity. This led to the discovery of new AChE inhibitors with the highest inhibitory activity of IC50 69.45±0.23  μM. A neurotoxicity evaluation revealed that hydroxyxanthones represented another class of compound that was non-toxic to the neuroblastoma cells at IC50 higher than 94  μM.

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How to Cite
Khammee, T., Athipornchai, A., Upamaia, W., Jaisin, Y., & Suksamrarn, S. (2014). Synthesis of Hydroxyxanthones and Evaluations for their Acetylcholinesterase Inhibitory and Neurotoxicity Activities. KKU Science Journal, 42(1), 212–220. retrieved from https://ph01.tci-thaijo.org/index.php/KKUSciJ/article/view/249255
Issue
Vol. 42 No. 1 (2014): January - March 2014
Section
Research Articles
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Author Biographies

Thongchai Khammee, Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110 Thailand

Department of Chemistry, Faculty of Science and Technology, Phranakhon Rajabhat University, Bangkok, 10220

Anan Athipornchai, Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240 Thailand

Department of Chemistry, Faculty of Science, Burapha University, Chon-Buri, 20131 Thailand