Synthesis of Hydroxyxanthones and Evaluations for their Acetylcholinesterase Inhibitory and Neurotoxicity Activities
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Abstract
A series of hydroxyxanthones has been synthesized and screened for their anti-AChE activity. This led to the discovery of new AChE inhibitors with the highest inhibitory activity of IC50 69.45±0.23 μM. A neurotoxicity evaluation revealed that hydroxyxanthones represented another class of compound that was non-toxic to the neuroblastoma cells at IC50 higher than 94 μM.
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Suksamrarn, S. ., Khammee, T. ., Athipornchai, A. ., Upamaia, W. ., & Jaisin, Y. (2022). Synthesis of Hydroxyxanthones and Evaluations for their Acetylcholinesterase Inhibitory and Neurotoxicity Activities. KKU Science Journal, 42(1), 212–220. Retrieved from https://ph01.tci-thaijo.org/index.php/KKUSciJ/article/view/249255
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Research Articles
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