Surface Modifications of Nanoparticles for Biomedical Application

Abstract

Applications of nanoparticles in biomedical science have been studied extensively because of their potentials to bring tremendous changes in diagnostic and treatment for many diseases. Firstly, however, surface of nanoparticles have to be modified in order to improve their physicochemical properties. In this review, it starts with a brief introduction regarding water solubilization of nanoparticles, followed by example approaches to solubilize them into aqueous solution such as ligand exchange, silica coating and polymer coating. Next, bioconjugate chemistry between nanoparticles and specific biomolecules was mentioned briefly. Finally, the selected biomedical applications of nanoparticles were also mentioned.