Evaluation of Various Starches as Binders and Properties for Ya-Hom Thepphachit Tablet

Authors

  • Khemika Kieng Na Fah Manok Department of Thai Traditional Medicine, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University Thailand
  • Sirikran Winyupan Department of Pharmacy, Faculty of Pharmacy, Mahasarakham University Thailand

Keywords:

Ya-Hom Thepphachit, Tablet, Binders

Abstract

The purpose of this research was to the evaluation of various starches as binders of Ya-Hom Thepphachit in tablet formula. The following physical properties of Thepphachit powders have been studied:  flow property, bulk density, tapped density, compressibility, hausner ratio, estimation of mixing uniformity, dissolution, moisture content etc., including the antioxidant activity of formula by DPPH, ABTS and FRAP methods. When, devided the extraction 3 methods: infusion by water, maceration by 95% ethanol and dissolution with flower water kasaiya. The tablets were quanlity control evaluate followed by United states pharmacopeia 40 (USP 40) such as weight variation, hardness, thickness, diameter, friability and disintegration time, when various binders 7 types using: tapioca starch (TS), glutinous rice flour (GRF), dark rye flour (DRF), finest rice flour (FRF), corn flour (CF), pure corn flour (PCF) and corn starch (CS). The study found that the Thepphachit powders has low flow property, hight moisture content because it contains fiber and essential oil of herbs, powder is fluffy and moisture. Thus, the direct compression were difficult and powders prepared in wet granulation. The 95% ethanol extract had the hightes antioxidant activity in DPPH assay (IC50 = 27.95 ± 4.78 mg/ml), ABTS assay (VEAC = 0.42 ± 0.01 mM/g and TEAC = 0.28 ± 0.01 mM/g) and FRAP assay (FRAP value = 0.72 ± 0.01 mM/g). From the property of tablet found that the CS is the best binder by higest hardness (2.82 ± 0.07 kp), low friability (0.0550 ± 0.02 %) and fastest disintegration time (17.91 ± 0.12 min). While, PCF and CF were the second most effective, respectively. At the same time, PCF (0.0081 ± 0.00 %) gave the better friability value more than CS. Alternative, PCF is the binder for instead CS for Ya-Hom Thepphachit formula because the quality of  PCF to be the same as CS tablets and lower friability.

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Published

2024-12-26