Evaluation of Various Starches as Binders and Properties for Ya-Hom Thepphachit Tablet
Keywords:
Ya-Hom Thepphachit, Tablet, BindersAbstract
Ya-Hom Thepphachit formula are Thai traditional medicine listed in the National List of Essential Medicine (NLEM), which wasthe powder infusedwith hot water. The development into tablet form often problem about flowability of herbal powder in direct compression. Therefore, solid dosage form the granulation preparation technique is commonly used.The purpose of this research was to the evaluation of various starches as binders of Ya-Hom Thepphachit in tablet formulaby usingthewet granulation technique. The following physical properties of Thepphachit powders have been studied: flow property, bulk density, tapped density, compressibility, hausner ratio, estimation of mixing uniformity, dissolution, moisture content etc., including the antioxidant activity of formula by DPPH, ABTS andFRAP methods. When, devided the extraction 3 methods: infusion by water, maceration by 95% ethanol and dispersion inkasaiya water from flowers.The tablets were quanlity control evaluate followed by United states pharmacopeia 40 (USP 40) such as weight variation, hardness, thickness, diameter, friability and disintegration time, when various binders 7 types using: tapioca starch (TS), glutinous rice flour (GRF), dark rye flour (DRF), finest rice flour (FRF), corn flour (CF), pure corn flour (PCF) and corn starch (CS). The study found that the Thepphachit powders has low flow properties, high moisture content because it contains fiber and essential oil of herbs, powder is fluffy and moisture. Thus, the direct compression wasdifficult and powders prepared in wet granulation. The 95% ethanol extract had the highestantioxidant activity in DPPH assay (IC50= 27.95± 4.78g/ml), ABTS assay (VEAC= 0.42 ± 0.01mM/gandTEAC= 0.28 ± 0.01mM/g)andFRAP assay (FRAP value= 0.72 ± 0.01mM/g). From evaluating the quality of tabletsfound that the CS is thebest binder by highest hardness (2.82 ± 0.07 kp), low friability (0.0550 ± 0.02 %) and fastest disintegration time (17.91 ± 0.12 min). While, PCF and CF were the second most effective, respectively. At the same time, PCF (0.0081 ± 0.00 %) gave abetter friability value than CS. Alternative, PCF is thebinder for instead CS for Ya-Hom Thepphachit formula because the quality of PCFisthe same as CS tablets andgives alower friability.
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