สารพฤกษเคมีจากพริกไทยดำและฤทธิ์ทางเภสัชวิทยา
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Published:
Nov 1, 2018
Keywords:
Piper nigrum
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Abstract
พริกไทยดำเป็นสมุนไพรพื้นบ้านที่นิยมใช้กันมาอย่างยาวนานและแพร่หลาย ผลของพริกไทยดำมีรสเผ็ดร้อน นิยมนำมาใช้ในการปรุงอาหารเพิ่มรสชาติและใช้เป็นยาสมุนไพรในการรักษาโรคบางชนิด โดยพบว่าภายในผลพริกไทยดำประกอบด้วยสารอัลคาลอยด์ ฟลาโวน ฟลาโวนอยด์ สเตียรอยด์ แทนนิน ซาโปนิน ฟีนอล ไกลโคไซด์ เทอร์ปีน และลิกแนน เป็นต้น ซึ่งสารเหล่านี้เป็นพฤกษเคมีที่มีฤทธิ์ทางเภสัชวิทยาหลากหลาย เช่น ต้านอาการท้องเสีย ต้านอาการหอบหืด ต้านการอักเสบ ป้องกันโรคหัวใจและหลอดเลือด ต้านอาการไข้ ต้านภาวะซึมเศร้า และต้านมะเร็งหลายชนิด ดังนั้นในบทความปริทัศน์นี้เป็นการรวบรวมสารพฤกษเคมีในพริกไทยดำพร้อมทั้งกลไกการออกฤทธิ์ทางเภสัชวิทยาของสารเหล่านั้น
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How to Cite
ข้อค้า อ. (2018). สารพฤกษเคมีจากพริกไทยดำและฤทธิ์ทางเภสัชวิทยา. PKRU SciTech Journal, 1(2), 28–39. Retrieved from https://ph01.tci-thaijo.org/index.php/pkruscitech/article/view/153065
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References
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[3] Parmar, V. S., Jain, C. S., Bisht, S. K., Jain, R., Taneja, P., Jha, A., et al. (1997). Phyto chemistry of the genus Piper. Phytochemis try, 46, 597–673.
[4] Shetty, S., Vijayalaxmi, K. K. (2017). Phyto chemical investigation of extract/solvent fractions of Piper nigrum Linn. seeds and Piper betle Linn. leaves. IJPBS, 3, 344-349.
[5] Gupta, A., Gupta, M., Gupta, S. (2013). Isolation of piperine and few sesquiter penes from the cold petroleum ether extract of Piper nigrum (black pepper) and its antibacterial activity. IJPPR, 5, 101-105.
[6] Orav, A., Stulova, I., Kailas, T., Müürisepp, M. (2004). Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states. J Agric Food Chem, 52, 2582-2586.
[7] Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Alhadrami, H. A., Bhandarib, A. (2015). Quantification of total phenol, flavonoid content and pharmacognostical evaluation including HPTLC fingerprinting for the standardization of Piper nigrum Linn fruits. Asian Pac J Trop Biomed, 5, 101-107.
[8] Rifai, Y., Aswad, M., Subehan. (2012). A new lignan from Piper nigrum fruit. IJCAS, 3, 1585-1586.
[9] Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., Mahmood, Z. A. (2014). Analgesic and antiinflammatory activities of Piper nigrum L. Asian Pac J Trop Med, 7 (Suppl 1), S461-S468.
[10] Bukhari, I. A., Alhumayyd, M. S., Mahesar, A. L., Gilani, A. H. (2013). The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol, 6, 789-794.
[11] Chonpathompikunlert, P., Wattanathorn, J., Muchimapura, S. (2010). Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive
impairment in animal model of cognitive deficit like condition of Alzhei mer's disease. Food Chem Toxicol, 48, 798-802.
[12] de Souza, G. V. M., Kviecinski, M. R., Santos, M. N. S., Ourique, F., Porfirio, C. L. S., Andreguetti, R. R., et al. (2016). Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells. J Ethnophar macol, 189, 139-47.
[13 Moura, C. D. F., Amaral, A.C., Machado, G. M., Leon, L. L., Silva, J. R. ( 2012). Chemical and biological analyses of the essential oils and main constituents of Piper species. Molecules, 17, 1819-1829.
[14] Zou, L., Hu, Y. Y., Chen, W. X. (2015). Antibacterial mechanism and activities of black pepper chloroform extract. J Food Sci Technol, 52, 8196–8203.
[15] Kalunta, C. G. (2017). Antimicrobial effect of different seed extracts of Piper nigrum against Escherichia coli, Staphylococcus aureus and Candida albican. Biotechnol Res, 3, 71-76.
[16] Nahak, G., Sahu, R.K. (2011). Phytochemi cal evaluation and antioxidant activity of Piper cubeba and Piper nigrum. J. Appl. Pharm. Sci., 8, 153-157.
[17] Shamkuwar, P. B., Shahi, S. R., Jadhav, S. T. (2012). Evaluation of antidiarrhoeal effect of black pepper (Piper nigrum L.). AJPSKY, 2, 48-53.
[18] Nelson, S. C., Cannon-Eger, K. T. (2011). Farm and forestry production and mar keting profile for black pepper (P. nigrum). USA: Permanent Agriculture Resources.
[19] Pradip, G., Vijay, C., Priya, S., Sujata, L., Mahendra, H., Harish, L., et al. (2014). Recent alkaloids from Dalbergia sissoo and various herbs as anticancer agents. Interna tional Journal of Traditional System of Medicine, 1, 28-33.
[20] Souza, M. T., Almeida, J. R., Araujo, A. A., Duarte, M. C., Gelain, D. P., Moreira, J. C., et al. ( 2 0 1 4 ) . Structure activity relationship of terpenes with anti-inflammatory profile – a systematic review. Basic Clin Pharmacol Toxicol, 115, 244-56.
[21] Dubreuil, J. D. (2013). Antibacterial and antidiarrheal activities of plant products against enterotoxinogenic Escherichia coli. Toxins. 5, 2009-2041.
[22] Pongkorpsakol, P., Wongkrasant, P., Kum pun, S., Chatsudthipong, V. , Muanprasat. C. (2015). Inhibition of intestinal chloride secretion by piperine as a cellular basis for the antisecretory effect of black peppers. Pharmacol Res, 100, 271-280.
[23] Bang, J. S., Oh, D. H., Choi, H. M., Sur, B., Lim, S., Kim, J. Y., et al. (2009). Anti-inflammatory and antiarthritic effects of piperine in human interleukin-1β-stimu
lated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther, 11, R49.
[24] Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., Mahmood, Z. A. (2014). Analgesic and antiinflammatory activities of Piper nigrum L. Asian Pac J Trop Med, 7 (Suppl 1), S461-8.
[25] Samykutty, A., Shetty, A., Dakshinamoor, G., Bartik, M., Johnson, G., et al. (2013). Piperine, a bioactive component of pepper spice exerts therapeutic effects on andro gen dependent and androgen independent prostate cancer cells. PLOS ONE, 8, e65889.
[26] Ouyang, D., Zeng, L., Pan, H., Xu, L., Wang, Y., Liu, K., et al. (2013). Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest
and autophagy. Food Chem Toxicol. 60, 424–430.
[27] Sruthi, D., Zachariah, T. (2017). In vitro antioxidant activity and cytotoxicity of sequential extracts from selected black pepper (Piper nigrum L.) varieties and Piper species. IFRJ. 24, 75-85.
[28] Zhang, L. L., Xu, J. G. (2015). Comparative study on antioxidant activity of essential oil from white and black pepper. EJFST, 3, 10-16.
[29] Rani, S. K., Neeti, S., Udaysree. (2013). Antimicrobial activity of black pepper (Piper nigrum L.). GJP, 7, 87-90.
[30] Taqvi, S. I. H., Shah, A. J., Gilani, A. H. (2008). Blood pressure lowering and vaso modulator effects of piperine. J Cardiovasc Pharmacol. 52, 452-458.
[31] Sabina, E. P., Nasreen, A., Vedi, M., Rasool, M. (2013). Analgesic, antipyretic and ulcerogenic effects of piperine: an active ingredient of pepper. J. Pharm. Sci. & Res. 5, 203-206.
[32] Pavani, A. N., Somashekara, S. C., Jagannat, N., Govindadas, D., Shravani, P. (2013). Anti-pyretic activity of Piper nigrum in Wistar albino rats. Int J Pharm Biomed
Res. 4, 167-169.
[33] da Cruz, G. M., Felipe, C. F., Scorza, F. A., da Costa, M. A., Tavares, A. F., Menezes, M. L., et al. (2013). Piperine decreases pilocarpine-induced convulsions by GABA ergic mechanisms. Pharmacol Biochem Behav, 104, 144-153.
[34] Mishra, A., Punia, J. K., Bladen, C., Zamponi, G. W., Goel, R. K. (2015). Anti convulsant mechanisms of piperine, a piperidine alkaloid. Channels. 5, 317-323.
[2] Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., Khan, M. A. (2012). Biological role of Piper nigrum L. (black pepper): A review. Asian Pac J Trop Biomed, 2, S1945–53.
[3] Parmar, V. S., Jain, C. S., Bisht, S. K., Jain, R., Taneja, P., Jha, A., et al. (1997). Phyto chemistry of the genus Piper. Phytochemis try, 46, 597–673.
[4] Shetty, S., Vijayalaxmi, K. K. (2017). Phyto chemical investigation of extract/solvent fractions of Piper nigrum Linn. seeds and Piper betle Linn. leaves. IJPBS, 3, 344-349.
[5] Gupta, A., Gupta, M., Gupta, S. (2013). Isolation of piperine and few sesquiter penes from the cold petroleum ether extract of Piper nigrum (black pepper) and its antibacterial activity. IJPPR, 5, 101-105.
[6] Orav, A., Stulova, I., Kailas, T., Müürisepp, M. (2004). Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states. J Agric Food Chem, 52, 2582-2586.
[7] Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Alhadrami, H. A., Bhandarib, A. (2015). Quantification of total phenol, flavonoid content and pharmacognostical evaluation including HPTLC fingerprinting for the standardization of Piper nigrum Linn fruits. Asian Pac J Trop Biomed, 5, 101-107.
[8] Rifai, Y., Aswad, M., Subehan. (2012). A new lignan from Piper nigrum fruit. IJCAS, 3, 1585-1586.
[9] Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., Mahmood, Z. A. (2014). Analgesic and antiinflammatory activities of Piper nigrum L. Asian Pac J Trop Med, 7 (Suppl 1), S461-S468.
[10] Bukhari, I. A., Alhumayyd, M. S., Mahesar, A. L., Gilani, A. H. (2013). The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol, 6, 789-794.
[11] Chonpathompikunlert, P., Wattanathorn, J., Muchimapura, S. (2010). Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive
impairment in animal model of cognitive deficit like condition of Alzhei mer's disease. Food Chem Toxicol, 48, 798-802.
[12] de Souza, G. V. M., Kviecinski, M. R., Santos, M. N. S., Ourique, F., Porfirio, C. L. S., Andreguetti, R. R., et al. (2016). Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells. J Ethnophar macol, 189, 139-47.
[13 Moura, C. D. F., Amaral, A.C., Machado, G. M., Leon, L. L., Silva, J. R. ( 2012). Chemical and biological analyses of the essential oils and main constituents of Piper species. Molecules, 17, 1819-1829.
[14] Zou, L., Hu, Y. Y., Chen, W. X. (2015). Antibacterial mechanism and activities of black pepper chloroform extract. J Food Sci Technol, 52, 8196–8203.
[15] Kalunta, C. G. (2017). Antimicrobial effect of different seed extracts of Piper nigrum against Escherichia coli, Staphylococcus aureus and Candida albican. Biotechnol Res, 3, 71-76.
[16] Nahak, G., Sahu, R.K. (2011). Phytochemi cal evaluation and antioxidant activity of Piper cubeba and Piper nigrum. J. Appl. Pharm. Sci., 8, 153-157.
[17] Shamkuwar, P. B., Shahi, S. R., Jadhav, S. T. (2012). Evaluation of antidiarrhoeal effect of black pepper (Piper nigrum L.). AJPSKY, 2, 48-53.
[18] Nelson, S. C., Cannon-Eger, K. T. (2011). Farm and forestry production and mar keting profile for black pepper (P. nigrum). USA: Permanent Agriculture Resources.
[19] Pradip, G., Vijay, C., Priya, S., Sujata, L., Mahendra, H., Harish, L., et al. (2014). Recent alkaloids from Dalbergia sissoo and various herbs as anticancer agents. Interna tional Journal of Traditional System of Medicine, 1, 28-33.
[20] Souza, M. T., Almeida, J. R., Araujo, A. A., Duarte, M. C., Gelain, D. P., Moreira, J. C., et al. ( 2 0 1 4 ) . Structure activity relationship of terpenes with anti-inflammatory profile – a systematic review. Basic Clin Pharmacol Toxicol, 115, 244-56.
[21] Dubreuil, J. D. (2013). Antibacterial and antidiarrheal activities of plant products against enterotoxinogenic Escherichia coli. Toxins. 5, 2009-2041.
[22] Pongkorpsakol, P., Wongkrasant, P., Kum pun, S., Chatsudthipong, V. , Muanprasat. C. (2015). Inhibition of intestinal chloride secretion by piperine as a cellular basis for the antisecretory effect of black peppers. Pharmacol Res, 100, 271-280.
[23] Bang, J. S., Oh, D. H., Choi, H. M., Sur, B., Lim, S., Kim, J. Y., et al. (2009). Anti-inflammatory and antiarthritic effects of piperine in human interleukin-1β-stimu
lated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther, 11, R49.
[24] Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., Mahmood, Z. A. (2014). Analgesic and antiinflammatory activities of Piper nigrum L. Asian Pac J Trop Med, 7 (Suppl 1), S461-8.
[25] Samykutty, A., Shetty, A., Dakshinamoor, G., Bartik, M., Johnson, G., et al. (2013). Piperine, a bioactive component of pepper spice exerts therapeutic effects on andro gen dependent and androgen independent prostate cancer cells. PLOS ONE, 8, e65889.
[26] Ouyang, D., Zeng, L., Pan, H., Xu, L., Wang, Y., Liu, K., et al. (2013). Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest
and autophagy. Food Chem Toxicol. 60, 424–430.
[27] Sruthi, D., Zachariah, T. (2017). In vitro antioxidant activity and cytotoxicity of sequential extracts from selected black pepper (Piper nigrum L.) varieties and Piper species. IFRJ. 24, 75-85.
[28] Zhang, L. L., Xu, J. G. (2015). Comparative study on antioxidant activity of essential oil from white and black pepper. EJFST, 3, 10-16.
[29] Rani, S. K., Neeti, S., Udaysree. (2013). Antimicrobial activity of black pepper (Piper nigrum L.). GJP, 7, 87-90.
[30] Taqvi, S. I. H., Shah, A. J., Gilani, A. H. (2008). Blood pressure lowering and vaso modulator effects of piperine. J Cardiovasc Pharmacol. 52, 452-458.
[31] Sabina, E. P., Nasreen, A., Vedi, M., Rasool, M. (2013). Analgesic, antipyretic and ulcerogenic effects of piperine: an active ingredient of pepper. J. Pharm. Sci. & Res. 5, 203-206.
[32] Pavani, A. N., Somashekara, S. C., Jagannat, N., Govindadas, D., Shravani, P. (2013). Anti-pyretic activity of Piper nigrum in Wistar albino rats. Int J Pharm Biomed
Res. 4, 167-169.
[33] da Cruz, G. M., Felipe, C. F., Scorza, F. A., da Costa, M. A., Tavares, A. F., Menezes, M. L., et al. (2013). Piperine decreases pilocarpine-induced convulsions by GABA ergic mechanisms. Pharmacol Biochem Behav, 104, 144-153.
[34] Mishra, A., Punia, J. K., Bladen, C., Zamponi, G. W., Goel, R. K. (2015). Anti convulsant mechanisms of piperine, a piperidine alkaloid. Channels. 5, 317-323.