Drug Selection Support System for Targeted Cancer Therapy Based on Cell Signal Transduction Pathways
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Abstract
This research proposed drug selection support system for targeted cancer therapy based on cell signal transduction pathways. Two graph traversal algorithms include depth first search (DFS) and breadth first search (BFS) algorithms were brought to apply with centrality measurements. There are called centrality depth first search (CDFS) algorithm. The CDFS was used to traverse in the cell signal transduction pathway for genes that related with the interested gene in the same pathway. Then the system will bring that genes to find drugs that can be used for targeted cancer therapy. Moreover, this research also developed scoring drug system for computing score of that drugs and ranking drugs according to their score. The results shown that drug selection support system for targeted cancer therapy based on signal transduction pathway can decrease time to analyze pathway and find drugs based on cell signal transduction pathway.
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