A Comprehensive Analysis of Diabetic Retinopathy Detection in Retinal Fundus Images Using Different Convolutional Neural Network
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Abstract
Diabetic Retinopathy (DR) harms the retinal tissue's blood vessels, causing them to leak fluid and results in permanent vision loss. Therefore, rigorous discussion and evaluation of the associated procedures and findings are necessary for DR detection. In this work, the Asia Pacific Tele-Ophthalmology Society 2019 Blindness Detection (APTOS 2019 BD) dataset and the High Resolution Fundus (HRF) datasets are utilized. The Contrast Limited Adaptive Histogram Equalization is employed in the preprocessing stage to enhance the quality of the fundus images. There are various popular edge detection algorithms utilized here like Robert, Sobel, Prewitt and Canny edge detector but our experimental findings have shown that the Canny edge detector performs better than its other counterparts. So, Canny has been used for the Segmentation of fundus images. Finally, the pretrained Convolutional Neural Networks namely MobileNet, InceptionV3, ResNet- 50, VGG16 and VGG19 are proposed to detect DR in retinal fundus images. To evaluate the effectiveness of the proposed model, both datasets are divided into two parts, where one part is utilized for training the proposed model and another part is utilized for testing the proposed model. The performances of different techniques are evaluated based on the standard performance parameters like Sensitivity, Specificity, Precision, Accuracy and Receiver Operating Characteristic Curve etc.
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References
P. Khojasteh, B. Aliahmad and D. K. Kumar, “Fundus images analysis using deep features for detection of exudates, hemorrhages and microaneurysms,” BMC Ophthalmology, vol. 18, no. 1, Nov. 2018.
S. Gnanamurthy and V. K. Kaliappan, “Cloud-based onboard prediction and diagnosis of diabetic retinopathy,” Concurrency and Computation: Practice and Experience, vol. 33, no. 24, Jun. 2021.
M. Mateen, J. Wen, N. Nasrullah, S. Sun and S. Hayat, “Exudate Detection for Diabetic Retinopathy Using Pretrained Convolutional Neural Networks,” Complexity, vol. 2020, pp. 1–11, Apr. 2020.
G. U. Nneji, J. Cai, J. Deng, H. N. Monday, M. A. Hossin and S. Nahar, “Identification of Diabetic Retinopathy Using Weighted Fusion Deep Learning Based on Dual-Channel Fundus Scans,” Diagnostics, vol. 12, no. 2, p. 540, Feb. 2022.
“APTOS-2019 dataset,” www.kaggle.com. https://www.kaggle.com/datasets/mariaherrerot/aptos2019 (accessed January 16, 2023).
“High-Resolution Fundus (HRF) Image Database,” www5.cs.fau.de. https://www5.cs.fau.de/research/data/fundus-images (accessed January 16, 2023).
A. Z. H. Ooi et al., “Interactive Blood Vessel Segmentation from Retinal Fundus Image Based on Canny Edge Detector,” Sensors, vol. 21, no. 19, p. 6380, Sep. 2021.
H. -r. Wang, J. -l. Yang, H. -j. Sun, D. Chen and X. -l. Liu, “An Improved Region Growing Method for Medical Image Selection and Evaluation Based on Canny Edge Detection,” 2011 International Conference on Management and Service Science, Wuhan, China, pp. 1-4, 2011.
W. Kusakunniran, P. Charoenpanich, P. Samunyanoraset, S. Suksai, S. Karnjanapreechakorn, Q. Wu and J. Zhang, “Hybrid Learning of Vessel Segmentation in Retinal Images,” ECTI Transactions on Computer and Information Technology (ECTI-CIT), vol. 15, no.1, pp. 1–11, 2020.
Y.H. Li, N.N. Yeh, S.J. Chen and Y.C. Chung, “Computer-Assisted Diagnosis for Diabetic Retinopathy Based on Fundus Images Using Deep Convolutional Neural Network,” Mobile Information Systems, vol. 2019, pp. 1–14, Jan. 2019.
B. Bulut, V. Kalın, B. B. Gu ̈ne ̧s and R. Khazhin, “Deep Learning Approach For Detection Of Retinal Abnormalities Based On Color Fundus Images,” 2020 Innovations in Intelligent Systems and Applications Conference (ASYU), Istanbul, Turkey, pp. 1-6, 2020.
E. Abitbol, A. Miere, J.B. Excoffier, CJ Mehanna, F. Amoroso, S Kerr, M Ortala and E.H. Souied, “Deep learning-based classification of retinal vascular diseases using ultra-widefield colour fundus photographs,” BMJ Open Ophthalmology, vol. 7, no. 1, pp. e000924, Feb. 2022.
A. Sungheetha and R. Sharma R, “Design an Early Detection and Classification for Diabetic Retinopathy by Deep Feature Extraction based Convolution Neural Network,” Journal of Trends in Computer Science and Smart Technology, June 2021, vol. 3, no. 2, pp. 81–94, Jul. 2021, DOI: https://doi.org/10.36548/jtcsst.2021.2.002.
G. Mushtaq and F. Siddiqui, “Detection of diabetic retinopathy using deep learning methodology,” IOP Conference Series: Materials Science and Engineering, vol. 1070, pp. 012049, Feb. 2021.
N. Khalifa, M. Loey, M. Taha, and H. Mohamed, “Deep Transfer Learning Models for Medical Diabetic Retinopathy Detection,” Acta Informatica Medica, vol. 27, no. 5, pp. 327, 2019.
S. Gupta, S. Thakur, and A. Gupta, “Optimized hybrid machine learning approach for smartphone based diabetic retinopathy detection,” Multimedia Tools and Applications, vol. 81, pp. 14475-14501, Feb. 2022.
P. Saranya, S. Prabakaran, R. Kumar and E. Das, “Blood vessel segmentation in retinal fundus images for proliferative diabetic retinopathy screening using deep learning,” The Visual Compute: International Journal of Computer Science, vol. 38, pp.977-992, Jan. 2021.
I. Qureshi, J. Ma, and Q. Abbas, “Diabetic retinopathy detection and stage classification in eye fundus images using active deep learning,” Multimedia Tools and Applications, vol. 80, no. 8, pp. 11691–11721, Jan. 2021.
A. Bilal, L. Zhu, A. Deng, H. Lu, and N. Wu, “AI-Based Automatic Detection and Classification of Diabetic Retinopathy Using U-Net and Deep Learning,” Symmetry, vol. 14, no. 7, pp. 1427, Jul. 2022.
R. Sundaram, R. KS, P. Jayaraman, and V. B, “Extraction of Blood Vessels in Fundus Images of Retina through Hybrid Segmentation Approach,” Mathematics, vol. 7, no. 2, pp. 169, Feb. 2019.
S. Albahli and G. Nabi Ahmad Hassan Yar, “Detection of Diabetic Retinopathy Using Custom CNN to Segment the Lesions,” Intelligent Automation & Soft Computing, vol. 33, no. 2, pp. 837–853, 2022.
R. K. Yazid and S. Samsuryadi, “Detection of Diabetic Retinopathy Using Convolutional Neural Network (CNN),” Computer Engineering and Applications Journal, vol. 11, no. 3, pp. 203–213, Oct. 2022.
S. Akbar and D. Midhunchakkaravarthy, “A novel 3D-CNN based feature extraction based classification for diabetic retinopathy(DR) detection,” Journal of Mechanics of Continua and Mathematical Sciences, vol.15, no. 2, p.103-117, Feb. 2020.
A. Ayala, T. Ortiz Figueroa, B. Fernandes and F. Cruz, “Diabetic Retinopathy Improved Detection Using Deep Learning,” Applied Sciences, vol. 11, no. 24, pp. 11970, Dec. 2021.
D. Das, S.K. Biswas and S. Bandyopadhyay, “Detection of Diabetic Retinopathy using Convolutional Neural Networks for Feature Extraction and Classification (DRFEC),” Multimedia Tools and Applications, pp. 1-59, Oct. 2022.
Y. R., V. Raja Sarobin M., R. Panjanathan, G. J. S., and J. A. L., “Diabetic Retinopathy Classification Using CNN and Hybrid Deep Convolutional Neural Networks,” Symmetry, vol. 14, no. 9, p. 1932, Sep. 2022.
Y.S. Devi and S.P. Kumar, “A deep transfer learning approach for identification of diabetic retinopathy using data augmentation,” IAES International Journal of Artificial Intelligence, vol. 11, no. 4, pp. 1287-1296. Dec. 2022.
H.R. Ismail and M.M. Hassan, “Bayesian deep learning methods applied to diabetic retinopathy disease: a review,” Indonesian Journal of Electrical Engineering and Computer Science, vol. 30, no. 2, pp. 1167-1177, May 2023.
P. Datta, P. Das and A. Kumar, “Hyperparameter tuning based gradient boosting algorithm for detection of diabetic retinopathy: an analytical review,” Bulletin of Electrical Engineering and Informatics, vol. 11 , no. 2, pp. 814-824, Apr. 2022.
U.W. Wasekar and R.K Bathla, “A review on supervised learning methodologies for detection of exudates in diabetic retinopathy,” Indonesian Journal of Electrical Engineering and Computer Science, vol. 23, no. 2, pp. 837-846, Aug. 2021.
Md. R. Islam et al., “Applying supervised contrastive learning for the detection of diabetic retinopathy and its severity levels from fundus images,” Computers in Biology and Medicine, vol. 146, pp. 105602–105602, May. 2022.
A.-O.Asia et al., “Detection of Diabetic Retinopathy in Retinal Fundus Images Using CNN Classification Models,” Electronics, vol. 11, no. 17, pp. 2740, 2022.
E. AbdelMaksoud, S. Barakat and M. Elmogy, “A computer-aided diagnosis system for detecting various diabetic retinopathy grades based on a hybrid deep learning technique,” Medical and Biological Engineering & Computing, vol. 60, no. 7, pp. 2015–2038, 2022.