Electrocardiogram signal processing of hemodialysis patients with hyperparathyroidism

Abstract

Currently, hemodialysis (HD) is a popular renal replacement therapy for the end stage renal disease (ESRD) patients. However, the hyperparathyroidism inducing cardiovascular system abnormalities has been remaining a serious problem for these patients. Consequently, the development of non-invasive monitoring methods for hyperparathyroidism has been necessary. In this study, the objective is to study and compare the standard deviation (SD) within the QRS duration of the electrocardiogram (ECG) between ESRD patient groups replaced by HD with normal parathyroid hormone (PTH < 300 pg/ml: N-PTH ) and hyperparathyroid hormone (PTH > 300 pg/ml: H-PTH). The 15 minutes of the lead II ECG recorded by Biopac MP 36 from each patient were analysed in the time domain for SD computation within QRS duration. The analysed result showed that the values of SD within QRS duration of H-PTH were statistical significantly lower than those of N-PTH (SD: H-PTH 0.0461 ± 0.014 vs N-PTH 0.0931 ± 0.039, p-value = 0.001) using the Mann- Whitney บ test. The benefits of the obtained result are not only the categorizing method for hyperparathyroidism patients but also the dialysis adequacy method for parathyroid hormone elimination of the hemodialysis process.