Transformation of artemisinin to deoxyartemisinin by Aspergillus terricola TISTR 3019

Authors

  • Angkana Wipatanawin Bio-organic Synthesis and Molecular Biochemistry, Department of Chemistry, Faculty of Science, Chiang Mai University
  • Wannipa Pipatsamut Bio-organic Synthesis and Molecular Biochemistry, Department of Chemistry, Faculty of Science, Chiang Mai University
  • Sirirat Chancharunee Bio-organic Synthesis and Molecular Biochemistry, Department of Chemistry, Faculty of Science, Chiang Mai University
  • Nisa Chawapun Department of Radiology, Faculty of Medicine, Chiang Mai University

Keywords:

artemisinin, transformation, Aspergillus terricola, deoxyartemisinin, cytotoxicity, antimicrobial activity

Abstract

Artemisinin, a sesquiterpene lactone endoperoxide compound, was transformed using Aspergillus terricola TISTR 3019. The transformed product was isolated from the culture broth and identified as deoxyartemisinin (yield 21%). Investigation of the biological activities of deoxyartemisinin was carried out in vitro for both antimicrobial and cytotoxic activities. Deoxyartemisinin showed more effective than artemisinin in inhibitory of cell growth against human mouse melanoma B16F10 (ATCC-CRL-6475) cell line. However, the transformed product derived from A. terricola TISTR 3019 did not exhibit antimicrobial activities against Salmonella typhimurium TISTR 292, Escherichia coli TISTR 780, Candida albicans BCC 5390 and Aspergillus niger TISTR 3254.

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Published

2018-09-04

Issue

Vol. 17 No. Special (2018): Vol.17, Special issue [2018] TSB2017

Section

Research Articles