Efficacy of Platelet-Rich Fibrin Compared with Platelet-Rich Plasma in Melasma Treatment

Abstract

This research conducted at Mae Fah Luang University Hospital explores the differential effectiveness of Platelet-Rich Fibrin (PRF) versus Platelet-Rich Plasma (PRP) in managing melasma, a challenging dermatological condition characterized by dark, uneven patches on the face, which can significantly impair the mental well-being and quality of life of sufferers. The study engaged 20 Thai women, aged 30 to 65, all with Fitzpatrick skin types III to VI.
Utilizing a split-face experimental design, each participant received PRP on one side of the face and PRF on the other side over a period of 12 weeks, allowing a controlled and direct comparison of the two treatments on the same individual. The effectiveness of the treatments was meticulously assessed using the Modified Melasma Area and Severity Index (mMASI), alongside Mexameter® measurements, which provided quantitative data on melanin and erythema indices—key parameters in evaluating the progression and treatment response of melasma. The findings revealed a statistically significant reduction in mMASI scores in PRF-treated areas compared to PRP, with PRF also demonstrating a significant decrease in melanin levels. These results suggest a superior efficacy of PRF over PRP for melasma treatment. Patient satisfaction, an integral component of the study, was gauged through a well-structured
questionnaire, revealing high overall contentment with both treatment modalities. Notably, the satisfaction levels were marginally higher for PRF, although not reaching statistical significance. This study underscores the potential of PRF as a more effective alternative to PRP in the treatment of melasma, paving the way for further research into its long-term benefits and broader clinical applications in dermatology.