Monitoring Blood Coagulation Behavior Using Quartz Crystal Microbalance with a Mason Equivalent Circuit Model
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Abstract
Blood clotting ability is a vital function of life forms, aiding survival when the body sustains cuts or wounds. Patients lacking this ability, or those on blood-thinning medications, can suffer from excessive bleeding, posing challenges for medical treatment. This is particularly relevant for dentists, as excessive bleeding may occur during tooth extractions or other dental procedures. Hence, there is a need for real-time blood coagulation detection. We propose using the quartz crystal microbalance (QCM) as a sensor. Its ability to detect mass loading and viscosity makes it feasible for coagulation testing in dental clinics. However, conventional equations like Sauerbrey’s and Kanazawa’s do not account for the dissipation factor, which plays a crucial role in determining liquid viscosity. We suggest using the Mason equivalent circuit model for interpreting blood viscosity and its clotting on the QCM surface. Observations show that film thickness increases with viscosity. Different samples exhibited varying viscosity changes, while the increase in film thickness was relatively comparable. This demonstrates the potential of the Mason equivalent Circuit model to differentiate results and estimate the underlying physical properties of blood coagulation.
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